Pulmonary Function Tests in Preschool Children with Cystic Fibrosis
Male
Cystic Fibrosis
Functional Residual Capacity
Airway Resistance
Homozygote
Cystic Fibrosis Transmembrane Conductance Regulator
Bronchodilator Agents
03 medical and health sciences
0302 clinical medicine
Child, Preschool
Respiratory Mechanics
Humans
Female
Tobacco Smoke Pollution
Child
DOI:
10.1164/rccm.200205-421oc
Publication Date:
2002-10-15T02:34:59Z
AUTHORS (10)
ABSTRACT
Pulmonary function tests have rarely been assessed in preschool children with cystic fibrosis (CF). The objective of this multicenter study was to compare pulmonary 39 CF (height, 90–130 cm; 16 homozygous ΔF508) and 79 healthy control children. Functional residual capacity (helium dilution technique) expiratory interrupter resistance (Rintexp) (interrupter were measured. As compared children, had significantly higher Rintexp, expressed as absolute values Z-scores (1.05 ± 0.36 versus 0.80 0.20 kPa·L−1 · second, p < 0.0001; 1.31 1.72 0.19 0.97, 0.0001), lower specific conductance (1.29 0.34 1.63 0.43 kPa−1 0.0001). effect the bronchodilator salbutamol on Rintexp not different between who exposed passive smoke (n = 8) (p 0.03). Children a history respiratory symptoms 31) functional 0.02) 0.04). Genotype did influence data. We conclude that measurements may help follow young are unable perform reproducible forced maneuvers.
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