Pulmonary Function Tests in Preschool Children with Cystic Fibrosis

• DOI: 10.1164/rccm.200205-421oc
• Publication Date: 2002-10-15T02:34:59Z
• Authors: Nicole Beydon; Francis Amsallem; Mireille Bellet; Michèle Boulé; Michèle Chaussain; André Denjean; Régis Matran; Isabelle Pin; Corinne Alberti; Claude Gaultier
• Keywords: Male; Cystic Fibrosis; Functional Residual Capacity; Airway Resistance; Homozygote; Cystic Fibrosis Transmembrane Conductance Regulator; Bronchodilator Agents; 03 medical and health sciences; 0302 clinical medicine; Child, Preschool; Respiratory Mechanics; Humans; Female; Tobacco Smoke Pollution; Child

Pulmonary function tests have rarely been assessed in preschool children with cystic fibrosis (CF). The objective of this multicenter study was to compare pulmonary 39 CF (height, 90–130 cm; 16 homozygous ΔF508) and 79 healthy control children. Functional residual capacity (helium dilution technique) expiratory interrupter resistance (Rintexp) (interrupter were measured. As compared children, had significantly higher Rintexp, expressed as absolute values Z-scores (1.05 ± 0.36 versus 0.80 0.20 kPa·L−1 · second, p < 0.0001; 1.31 1.72 0.19 0.97, 0.0001), lower specific conductance (1.29 0.34 1.63 0.43 kPa−1 0.0001). effect the bronchodilator salbutamol on Rintexp not different between who exposed passive smoke (n = 8) (p 0.03). Children a history respiratory symptoms 31) functional 0.02) 0.04). Genotype did influence data. We conclude that measurements may help follow young are unable perform reproducible forced maneuvers.