Pulmonary Function Tests in Preschool Children with Cystic Fibrosis

Male Cystic Fibrosis Functional Residual Capacity Airway Resistance Homozygote Cystic Fibrosis Transmembrane Conductance Regulator Bronchodilator Agents 03 medical and health sciences 0302 clinical medicine Child, Preschool Respiratory Mechanics Humans Female Tobacco Smoke Pollution Child
DOI: 10.1164/rccm.200205-421oc Publication Date: 2002-10-15T02:34:59Z
ABSTRACT
Pulmonary function tests have rarely been assessed in preschool children with cystic fibrosis (CF). The objective of this multicenter study was to compare pulmonary 39 CF (height, 90–130 cm; 16 homozygous ΔF508) and 79 healthy control children. Functional residual capacity (helium dilution technique) expiratory interrupter resistance (Rintexp) (interrupter were measured. As compared children, had significantly higher Rintexp, expressed as absolute values Z-scores (1.05 ± 0.36 versus 0.80 0.20 kPa·L−1 · second, p < 0.0001; 1.31 1.72 0.19 0.97, 0.0001), lower specific conductance (1.29 0.34 1.63 0.43 kPa−1 0.0001). effect the bronchodilator salbutamol on Rintexp not different between who exposed passive smoke (n = 8) (p 0.03). Children a history respiratory symptoms 31) functional 0.02) 0.04). Genotype did influence data. We conclude that measurements may help follow young are unable perform reproducible forced maneuvers.
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