Inhaled Corticosteroids and Hip Fracture

• DOI: 10.1164/rccm.200206-606oc
• Publication Date: 2002-12-06T21:25:31Z
• Authors: Richard B. Hubbard; Chris J. P. Smith; Liam Smeeth; Tim W. Harrison; Anne E. Tattersfield
• Keywords: Hip Fracture

There is accumulating evidence that the use of inhaled corticosteroids associated with a dose-related reduction in bone mineral density. Whether this translates to an increase fracture unclear. We have used General Practice Research Database perform case-control analysis, including 16,341 cases hip (mean age 79 years, 79% female, median period prescribing data 2.7 years) and 29,889 control subjects, individually matched by age, sex, general practice. Data for all prescriptions potential confounders, other drug comorbid illnesses, were extracted, impact corticosteroid exposure was analyzed using conditional logistic regression. The risk odds ratio 1.26 (95% confidence interval, 1.17 1.36). This reduced after adjusting model annual courses oral corticosteroids, only confounder note (OR 1.19; 95% CI, 1.10 1.28). dose-response relationship between even number (p trend = 0.007). In older recent fracture.