Particulate Matter Exposure in Cars Is Associated with Cardiovascular Effects in Healthy Young Men
Adult
Male
Air Pollutants
Inhalation Exposure
Autonomic Nervous System
01 natural sciences
Blood Coagulation Factors
Police
3. Good health
Cardiovascular Physiological Phenomena
Hemoglobins
03 medical and health sciences
0302 clinical medicine
Reference Values
Occupational Exposure
11. Sustainability
Humans
Inflammation Mediators
Vehicle Emissions
0105 earth and related environmental sciences
DOI:
10.1164/rccm.200310-1463oc
Publication Date:
2004-02-17T01:33:24Z
AUTHORS (8)
ABSTRACT
Exposure to fine airborne particulate matter (PM2.5) is associated with cardiovascular events and mortality in older cardiac patients. Potential physiologic effects of in-vehicle, roadside, ambient PM2.5 were investigated young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troopers (age 23 30) monitored on 4 successive days while working a 3 P.M. midnight shift. Each patrol car was equipped air-quality monitors. Blood drawn 14 hours after each shift, ambulatory monitors recorded the electrocardiogram throughout shift until next morning. Data analyzed using mixed models. In-vehicle (average 24 μg/m3) decreased lymphocytes (−11% per 10 increased red blood cell indices (1% mean corpuscular volume), neutrophils (6%), C-reactive protein (32%), von Willebrand factor (12%), next-morning heart beat cycle length rate variability parameters, ectopic beats recording (20%). Controlling for potential confounders had little impact effect estimates. The associations these health endpoints roadside smaller less significant. observations healthy young men suggest that in-vehicle exposure may cause pathophysiologic changes involve inflammation, coagulation, rhythm.
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