Particulate Matter Exposure in Cars Is Associated with Cardiovascular Effects in Healthy Young Men

Adult Male Air Pollutants Inhalation Exposure Autonomic Nervous System 01 natural sciences Blood Coagulation Factors Police 3. Good health Cardiovascular Physiological Phenomena Hemoglobins 03 medical and health sciences 0302 clinical medicine Reference Values Occupational Exposure 11. Sustainability Humans Inflammation Mediators Vehicle Emissions 0105 earth and related environmental sciences
DOI: 10.1164/rccm.200310-1463oc Publication Date: 2004-02-17T01:33:24Z
ABSTRACT
Exposure to fine airborne particulate matter (PM2.5) is associated with cardiovascular events and mortality in older cardiac patients. Potential physiologic effects of in-vehicle, roadside, ambient PM2.5 were investigated young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troopers (age 23 30) monitored on 4 successive days while working a 3 P.M. midnight shift. Each patrol car was equipped air-quality monitors. Blood drawn 14 hours after each shift, ambulatory monitors recorded the electrocardiogram throughout shift until next morning. Data analyzed using mixed models. In-vehicle (average 24 μg/m3) decreased lymphocytes (−11% per 10 increased red blood cell indices (1% mean corpuscular volume), neutrophils (6%), C-reactive protein (32%), von Willebrand factor (12%), next-morning heart beat cycle length rate variability parameters, ectopic beats recording (20%). Controlling for potential confounders had little impact effect estimates. The associations these health endpoints roadside smaller less significant. observations healthy young men suggest that in-vehicle exposure may cause pathophysiologic changes involve inflammation, coagulation, rhythm.
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