Outcome of Asthma and Wheezing in the First 6 Years of Life

• DOI: 10.1164/rccm.200504-525oc
• Publication Date: 2005-08-19T00:45:00Z
• Authors: Wayne J. Morgan; Debra A. Stern; Duane L. Sherrill; Stefano Guerra; Catharine J. Holberg; Theresa W. Guilbert; Lynn M. Taussig; Anne L. Wright; Fernando D. Martinez
• Keywords: Wheeze; Atopy; Respiratory sounds

The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based the occurrence lower illnesses before age 3 yr active wheeze at 6 yr: never wheezers (n = 425), transient 164), persistent 113), late-onset 124).We sought to determine prognosis for these phenotypes, with reference lung symptoms, adolescence.Current was assessed by questionnaire, measured conventional spirometry, atopy determined skin prick tests.The prevalence 16 similar wheezers. Both early, had significantly FEF(25-75) (-259 ml/s, p < 0.001, -260 respectively), FEV1 (-75 ml, 0.02, -87 0.03, FEV1:FVC ratio (-1.9%, 0.002, -2.5%, respectively) compared Late-onset levels those yr. There no significant change among subjects any relative their peers, yr.Patterns are established do appear children who start having asthma-like during preschool years.