Role of Secretoglobin 3A2 in Lung Development

• DOI: 10.1164/rccm.200707-1104oc
• Publication Date: 2008-06-06T01:36:04Z
• Authors: Reiko Kurotani; Takeshi Tomita; Qian Yang; Bradley A. Carlson; Chi Chen; Shioko Kimura
• Keywords: Organogenesis

Secretoglobin 3A2 (SCGB3A2) was originally identified as a downstream target in lung for the homeodomain transcription factor NKX2-1, whose null mutation resulted severely hypoplastic lungs. A very low level of SCGB3A2 is expressed lungs at Embryonic Day (E) 11.5 during mouse development, which markedly increases by E16.5, time when undergoes dramatic morphologic changes, suggesting that may be involved development addition to known role inflammation.To determine whether plays development.To assess potential early wild-type and Nkx2-1-null fetal developmental stages were subjected ex vivo organ culture presence SCGB3A2. fetuses exposed organogenesis period through intravenous administration this protein Nkx2-1-heterozygous pregnant females carrying these fetuses. Cultured histologic immunohistochemical analyses. To late administered mid- stages, preterm pups and/or their evaluated extent maturity using breathing motion, gross morphology histology lungs, expression gestational stage-specific genes, phospholipid profiles.SCGB3A2 significantly promoted both development.SCGB3A2 novel growth lung.