Randomized Controlled Trial of Dietary Creatine as an Adjunct Therapy to Physical Training in Chronic Obstructive Pulmonary Disease

• DOI: 10.1164/rccm.200710-1508oc
• Publication Date: 2008-07-24T01:31:51Z
• Authors: Sarah J. Deacon; Emma E. Vincent; Paul L. Greenhaff; John Fox; Michael C. Steiner; Sally J. Singh; Michael D. Morgan
• Keywords: Creatine

Rationale: Skeletal muscle strength and bulk are reduced in patients with chronic obstructive pulmonary disease (COPD) influence quality of life, survival, utilization health care resources. Exercise training during rehabilitation (PR) can reverse some these effects. In athletes healthy elderly individuals, dietary creatine supplementation (CrS) has been shown to augment high-intensity exercise training, thereby increasing mass.Objectives: This article examines the effect CrS on functional capacity performance people COPD.Methods: One hundred subjects COPD (mean [SD] age, 68.2 [8.2] yr; FEV1, 44.0 [19.6] %predicted) were randomized a double-blind, placebo-controlled, parallel group trial 7 weeks PR encompassing aerobic resistance exercises. Subjects ingested (22 g/d loading for 5 d; maintenance, 3.76 throughout PR) or placebo. Baseline, postloading, postrehabilitation measurements included function, body composition, peripheral strength, (shuttle walking tests). A volunteer subgroup (n = 44) had pre- postloading quadriceps biopsies.Measurements Main Results: Eighty completed (38 creatine, 42 placebo). All outcome measures significantly improved after PR. There no significant differences between groups post-PR change incremental shuttle walk distance, 84 [79] m vs. 83.8 [60] placebo group; P 1.0; knee extensor work, 19.2 [16] Nm [Newton meters] 19.5 [17] 0.9). Muscle biopsies showed evidence uptake.Conclusions: adequately powered, randomized, placebo-controlled shows that does not substantial multidisciplinary COPD.Clinical registered https://portal.nihr.ac.uk/Pages/NRRArchiveSearch.aspx (NO123138126).