Daily Telemonitoring of Exhaled Nitric Oxide and Symptoms in the Treatment of Childhood Asthma

• DOI: 10.1164/rccm.200807-1010oc
• Publication Date: 2008-10-18T01:32:32Z
• Authors: Johan C. de Jongste; Silvia Carraro; Wim C. Hop; ; Eugenio Baraldi
• Keywords: Exhalation

Rationale: Asthma treatment might improve when inhaled steroids are titrated on airway inflammation. Fractional exhaled nitric oxide (FeNO0.05), a marker of eosinophilic inflammation, can be measured at home.Objectives: We assessed daily FeNO0.05 telemonitoring in the management childhood asthma.Methods: Children with atopic asthma (n = 151) were randomly assigned to two groups: plus symptom monitoring, or monitoring symptoms only. All patients scored an electronic diary over 30 weeks; 77 received portable (NO) analyzer. Data transmitted coordinating centers. Patients phoned every 3 weeks and their steroid dose was adapted according symptoms, symptoms. seen 3, 12, 21, for examination lung function testing. The primary end point proportion symptom-free days last 12 study weeks.Measurements Main Results: Telemonitoring feasible reliable data 86% days, valid entries 79% days. Both groups showed increase improvement FEV1 quality life, reduction dose. None changes from baseline differed between groups. difference 0.3% (P 0.95; 95% confidence interval, −10 11%). There trend fewer exacerbations group.Conclusions: Thirty associated improved control lower found no added value compared