Continuous Positive Airway Pressure Treatment Reduces Mortality in Patients with Ischemic Stroke and Obstructive Sleep Apnea

• DOI: 10.1164/rccm.200808-1341oc
• Publication Date: 2009-05-01T01:10:39Z
• Authors: Miguel Ángel Mart...; Juan José Soler-C...; Laura Ejarque-Mar...; Youssef Soriano; Pilar Román-Sánchez; Ferrán Barbé Illa; Josep María Monts...; Joaquín Durán-Can...
• Keywords: Stroke

Obstructive sleep apnea (OSA) is an independent risk factor for stroke, but little known about the role of continuous positive airway pressure (CPAP) on mortality in patients with stroke.To analyze impact long-term CPAP treatment ischemic stroke.Prospective observational study 166 stroke. Sleep was performed all them and offered case moderate to severe cases. Patients were followed-up 5 years mortality.Of 223 consecutively admitted a (2 mo after acute event). Thirty-one had apnea-hypopnea index (AHI) less than 10; 39 AHI between 10 19, 96 20 or greater. when followed up our outpatient clinic at 1, 3, 6 months, every months thereafter (prospective study). Mortality data recorded from computer database official death certificates. The mean age subjects 73.3 +/- 11 (59% males), 26 (for predominance obstructive events). greater who did not tolerate (n = 68) showed increase adjusted (hazards ratio [HR], 2.69; 95% confidence interval [CI], 1.32-5.61) compared 70), increased (HR, 1.58; CI, 1.01-2.49; P 0.04) OSA tolerated 28). There no differences among without OSA, mild disease, CPAP.Our results suggest that stroke associated reduction excess mortality.