Elevated Exhaled Nitric Oxide in High-Risk Neonates Precedes Transient Early but Not Persistent Wheeze

• DOI: 10.1164/rccm.200909-1377oc
• Publication Date: 2010-07-16T05:43:24Z
• Authors: Bo L. K. Chawes; Frederik Buchvald; Anne Louise Bischoff; Lotte Loland; Mette Hermansen; Liselotte B. Halkjær; Klaus Bønnelykke; Hans Bisgaard
• Keywords: Wheeze; Atopy

Rationale: Elevated fractional exhaled nitric oxide (FeNO) concentration has been suggested to predict early childhood wheeze and sensitization.Objectives: To investigate the association between FeNO in asymptomatic neonates development of patterns atopic intermediary phenotypes first 6 years life.Methods: We measured 253 healthy 1-month-old from Copenhagen Prospective Study on Asthma Childhood birth cohort monitored prospectively wheezy episodes by daily diary cards during life. Total IgE, specific blood eosinophil count were assessed at age months, 4 years, years. Associations studied Cox regression, logistic generalized linear models.Measurements Main Results: Increased neonatal level was significantly associated with recurrent year life (hazard ratio, 2.63; 95% confidence interval, 1.1 6.2; P = 0.026) but not thereafter. The unaffected environmental tobacco smoke exposure. elevated levels total or any point unrelated lung function.Conclusions: An born mothers asthma preceded transient wheezing, persistent wheezing preschool age, atopy. This suggests an disease process other than small airway caliber contributing phenotype.