Mast Cell Phenotype, Location, and Activation in Severe Asthma

• DOI: 10.1164/rccm.201002-0295oc
• Publication Date: 2010-09-03T02:22:57Z
• Authors: Silvana Balzar; Merritt L. Fajt; Suzy A. A. Comhair; Serpil C. Erzurum; Eugene Bleecker; William W. Busse; Mario Castro; Benjamin Gaston; Elliot Israel; Lawrence B. Schwartz; Douglas Curran-Ev...; Charity G. Moore; Sally E. Wenzel
• Keywords: Tryptase; Chymase; Immunostaining; Pathogenesis; Prostaglandin D2

Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in pathogenesis, but it unknown how their phenotype, location, and activation relate to severity.