Viral Infection in Patients with Severe Pneumonia Requiring Intensive Care Unit Admission

• DOI: 10.1164/rccm.201112-2240oc
• Publication Date: 2012-06-15T06:00:33Z
• Authors: Sang-Ho Choi; Sang-Bum Hong; Gwang-Beom Ko; Yumi Lee; Hyun Jung Park; So-Youn Park; Song Mi Moon; Oh-Hyun Cho; Ki-Ho Park; Yong Pil Chong; Sung-Han Kim; Jin Won Huh; Heungsup Sung; Kyung-Hyun Do; Sang-Oh Lee; Mi-Na Kim; Jin-Yong Jeong; Chae-Man Lim; Yang Soo Kim; Jun Hee Woo; Younsuck Koh
• Keywords: Rhinovirus; Viral Pneumonia; Bacterial pneumonia; Human Parainfluenza Virus; Viral culture

Rationale: The role of viruses in pneumonia adults and the impact viral infection on mortality have not been elucidated. Previous studies significant limitations that they relied predominantly upper respiratory specimens.Objectives: To investigate adult patients with requiring intensive care unit (ICU) admission.Methods: A retrospective analysis a prospective cohort was conducted 28-bed medical ICU. Patients severe community-acquired (CAP) or healthcare-associated (HCAP) were included study.Measurements Main Results: total 198 (64 CAP, 134 HCAP) for analysis. Of these, 115 (58.1%) underwent bronchoscopic bronchoalveolar lavage (BAL), 104 whom tested by BAL fluid reverse-transcription polymerase chain reaction (RT-PCR). Nasopharyngeal specimen RT-PCR performed 159 (84.1%). Seventy-one (35.9%) had bacterial infection, 72 (36.4%) infection. Rhinovirus most common identified virus (23.6%), followed parainfluenza (20.8%), human metapneumovirus (18.1%), influenza (16.7%), syncytial (13.9%). Respiratory significantly more CAP group (CAP, 10.9%; HCAP, 2.2%; P = 0.01). mortalities infections, bacterial-viral coinfections different (25.5, 26.5, 33.3%, respectively; 0.82).Conclusions: Viruses are frequently found airway ICU admission may cause forms pneumonia. comparable rates.