Assessment of Pulmonary Neutrophilic Inflammation in Emphysema by Quantitative Positron Emission Tomography

• DOI: 10.1164/rccm.201201-0051oc
• Publication Date: 2012-07-27T21:31:30Z
• Authors: Deepak R. Subrama...; Lee Jenkins; Ross Edgar; Nabil Quraishi; Robert A. Stockley; David G. Parr
• Keywords: Imaging biomarker; Surrogate endpoint; Fluorodeoxyglucose

Rationale: Neutrophilic inflammation is understood to be of pathogenetic importance in chronic obstructive pulmonary disease (COPD) and may quantified using 18-fluorodeoxyglucose positron emission tomography–computed tomography (18FDG PET-CT) as a noninvasive, spatially informative biomarker.Objectives: To assess the potential usefulness 18FDG PET-CT surrogate measure neutrophilic patients with usual COPD α1-antitrypsin deficiency (AATD).Methods: imaging was performed 10 COPD, AATD, healthy control subjects. Pulmonary uptake estimated by three-dimensional Patlak graphical analysis an indicator glycolytic activity. Patients AATD were treated 12 weekly intravenous infusions AAT augmentation therapy before repeat imaging. uptake, lung physiology, density, systemic markers compared for all groups at baseline and, on treatment.Measurements Main Results: upper greater group (P = 0.009) correlated measures severity (FEV1% predicted, r −0.848, P 0.001; FEV1/FVC, −0.918, < Kco% −0.624, 0.027; 15th percentile point, −0.709, 0.011). No significant difference observed between measurements treatment AATD.Conclusions: Quantitative has role biomarker mechanistic interventional studies COPD. The data support previous evidence distinct functional characteristics neutrophils COPD.Clinical trial registered https://eudract.ema.europa.eu/index.html (EudraCT 2007-004869-18).