Timing and Duration of Traffic-related Air Pollution Exposure and the Risk for Childhood Wheeze and Asthma

• DOI: 10.1164/rccm.201407-1314oc
• Publication Date: 2015-06-24T19:44:35Z
• Authors: Kelly J. Brunst; Patrick H. Ryan; Cole Brokamp; David Bernstein; Tiina Reponen; James Lockey; Gurjit K. Khurana...; Linda Levin; Sergey A. Grinshpun; Grace LeMasters
• Keywords: Wheeze; Respiratory sounds

The timing and duration of traffic-related air pollution (TRAP) exposure may be important for childhood wheezing asthma development.We examined the relationship between TRAP longitudinal phenotypes at age 7 years.Children completed clinical examinations annually from 1 year through 4 years years. Parental-reported was assessed each age, (early-transient, late-onset, persistent) were defined Participants' time-weighted to TRAP, birth years, estimated using a land-use regression model. examined.High significantly associated with both transient persistent (adjusted odds ratio [aOR] = 1.64; 95% confidence interval [CI], 1.04-2.57 aOR 2.31; CI, 1.28-4.15, respectively); 2 also wheeze. Only children high average increased risk (aOR 1.71; 1.01-2.88).Early-life is wheezing, but only long-term levels throughout development.