Plasma Sphingolipids Associated with Chronic Obstructive Pulmonary Disease Phenotypes

• DOI: 10.1164/rccm.201410-1771oc
• Publication Date: 2014-12-10T20:47:50Z
• Authors: Russell P. Bowler; Sean Jacobson; Charmion Cruickshank; Grant J. Hughes; Charlotte Siska; Daniel S. Ory; Irina Petrache; Jean E. Schaffer; Nichole Reisdorph; Katerina Kechris
• Keywords: Sphingolipid

Chronic obstructive pulmonary disease (COPD) occurs in a minority of smokers and is characterized by intermittent exacerbations clinical subphenotypes such as emphysema chronic bronchitis. Although sphingolipids class are implicated the pathogenesis COPD, particular sphingolipid species associated with COPD remain unknown.To use mass spectrometry to determine which plasma COPD.One hundred twenty-nine current former from COPDGene cohort had 69 distinct detected targeted spectrometry. Of these, 23 were also measured 131 samples (117 independent subjects) using an untargeted platform laboratory. Regression analysis adjustment for covariates, correction false discovery rate, metaanalysis used test associations between sphingolipids. Peripheral blood mononuclear cells gene expression sphingolipids.Of sphingolipids, five sphingomyelins emphysema; four trihexosylceramides three dihexosylceramides exacerbations. Three strongly expression, 15 gene/metabolite pairs differentially regulated cases control subjects.There evidence systemic dysregulation metabolism patients COPD. Subphenotyping suggests that glycosphingolipids