Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma

• DOI: 10.1164/rccm.201411-1990oc
• Publication Date: 2015-02-18T16:37:51Z
• Authors: Amisha V. Barochia; Maryann Kaler; Rosemarie A. Cuento; Elizabeth M. Gordon; Nargues A. Weir; Maureen Sampson; Joseph R. Fontana; Sandra MacDonald; Joel Moss; Vincent Manganiello; Alan T. Remaley; Stewart J. Levine
• Keywords: Lipoprotein(a)

Although lipids, apolipoproteins, and lipoprotein particles are important modulators of inflammation, varying relationships exist between these parameters asthma.To determine whether serum lipids apolipoproteins correlate with the severity airflow obstruction in subjects atopy asthma.Serum samples were obtained from 154 atopic nonatopic without asthma, 159 asthma. Serum lipid levels quantified using standard diagnostic assays nuclear magnetic resonance (NMR) spectroscopy. Airflow was assessed by FEV1% predicted.Serum correlated FEV1 only high-density (HDL) cholesterol apolipoprotein A-I (apoA-I) positively whereas a negative correlation existed triglycerides, low-density (LDL) cholesterol, B (apoB), apoB/apoA-I ratio. NMR spectroscopy identified positive HDLNMR particle size, as well concentrations large total IDLNMR (intermediate-density lipoprotein) In contrast, LDLNMR size VLDLNMR (very-low-density negatively asthma.In apoA-I FEV1, LDL apoB associated more severe obstruction. These results may facilitate future studies to assess can reduce disease