Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease

• DOI: 10.1164/rccm.201502-0387oc
• Publication Date: 2015-06-03T20:39:14Z
• Authors: Eva P. Szymanski; Janice M. Leung; Cedar J. Fowler; Carissa Haney; Amy P. Hsu; Fei Chen; Priya Duggal; Andrew J. Oler; Ryan McCormack; Eckhard Podack; Rebecca A. Drummond; Michail S. Lionakis; Sarah K. Browne; D. Rebecca Prevots; Michael Knowles; Gary Cutting; Xinyue Liu; Scott E. Devine; Claire M. Fraser; Hervé Tettelin; Kenneth N. Olivier; Steven M. Holland
• Keywords: Adult; Aged, 80 and over; Male; Principal Component Analysis; Immunity; Cystic Fibrosis Transmembrane Conductance Regulator; Genetic Variation; Mycobacterium Infections, Nontuberculous; Middle Aged; 3. Good health; Causality; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Connective Tissue; Case-Control Studies; Humans; Exome; Family; Female; Genetic Predisposition to Disease; Cilia; Aged

Rationale: The clinical features of patients infected with pulmonary nontuberculous mycobacteria (PNTM) are well described, but the genetic components of infection susceptibility are not.