Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans

• DOI: 10.1164/rccm.201508-1599oc
• Publication Date: 2016-01-08T22:08:06Z
• Authors: Desinia B. Miller; Andrew J. Ghio; Edward D. Karoly; Lauren N. Bell; Samantha J. Snow; Michael C. Madden; Joleen Soukup; Wayne E. Cascio; M. Ian Gilmour; Urmila P. Kodavanti
• Keywords: Adult; Glycerol; Male; 0303 health sciences; Cross-Over Studies; Hydrocortisone; Fatty Acids, Nonesterified; Lipid Metabolism; Lipids; 3. Good health; Young Adult; 03 medical and health sciences; Ozone; 13. Climate action; Humans; Metabolomics; Monoglycerides; Female; Corticosterone; Biomarkers

Rationale: Air pollution has been associated with increased prevalence of type 2 diabetes; however, the mechanisms remain unknown. We have shown that acute ozone exposure in rats induces release of stress hormones, hyperglycemia, leptinemia, and glucose intolerance that are associated with global changes in peripheral glucose, lipid, and amino acid metabolism.