Physical Activity, Air Pollution, and the Risk of Asthma and Chronic Obstructive Pulmonary Disease

• DOI: 10.1164/rccm.201510-2036oc
• Publication Date: 2016-09-21T20:28:55Z
• Authors: Jack E. Fisher; Steffen Loft; Charlotte S. Ulrik; Ole Raaschou-Nielsen; Ole Hertel; Anne Tjønneland; Kim Overvad; Mark J. Nieuwenhu...; Zorana J. Andersen
• Keywords: 0301 basic medicine; 0303 health sciences; Physical activity; Chronic obstructive pulmonary disease; air pollution; Air pollution; physical activity; morbidity; asthma; Asthma; 796; chronic obstructive pulmonary disease; 3. Good health; 03 medical and health sciences; 13. Climate action; 11. Sustainability; Morbidity

Rationale: Physical activity enhances uptake of air pollutants in the lung, possibly augmenting their harmful effects on chronic lung disease during exercise.Objectives: To examine whether benefits physical with respect to risk asthma and obstructive pulmonary (COPD) are moderated by exposure high pollution levels an urban setting.Methods: A total 53,113 subjects (50–65 yr) from Danish Diet, Cancer, Health cohort reported at recruitment (1993–1997) were followed until 2013 National Patient Register for incident hospitalizations COPD. Levels nitrogen dioxide (NO2) estimated subject residences time recruitment. We used Cox regression associate activities NO2 (high/medium/low) COPD, then introduced interaction term between each NO2.Measurements Main Results: 1,151 hospitalized 3,225 COPD 16 years. found inverse associations participation sports (hazard ratio [95% confidence interval]: 0.85 [0.75–0.96]) cycling (0.85 asthma, (0.82 [0.77–0.89]), (0.81 [0.76–0.87]), gardening (0.88 [0.81–0.94]), walking [0.75–0.95]) admissions. positive (1.23 [1.04–1.47]) (1.15 [1.03–1.27]) (comparing ≥21.0 μg/m3 <14.3 μg/m3). no any or hospitalizations.Conclusions: Increased exercise does not outweigh beneficial