Evaluation of the Global Lung Initiative 2012 Reference Values for Spirometry in African Children

• DOI: 10.1164/rccm.201604-0693oc
• Publication Date: 2016-08-26T18:02:47Z
• Authors: Michele Arigliani; Mario C. Canciani; Giovanni Mottini; Michele Altomare; Andrea Magnolato; Sofia Vanda Loa C...; Leon Tshilolo; Paola Cogo; Philip H. Quanjer
• Keywords: Reference values

Despite the high burden of respiratory disease, no spirometry reference values for African children are available.Investigate whether Global Lung Initiative (GLI-2012) appropriate in sub-Saharan Africa and assess impact malnutrition on lung function.Anthropometry were obtained aged 6 to 12 years from urban semiurban schools three countries. Spirometry z-scores derived using GLI-2012 prediction equations Americans. Thinness (body mass index z-score < -2) was a surrogate malnutrition. outcomes compared with those American third National Health Nutrition Survey.Spirometry data analyzed 1,082 schoolchildren (51% boys) 6.0 12.8 Angola (n = 306), Democratic Republic Congo 377), Madagascar 399). provided good fit mean (SD) -0.11 (0.83) FEV1, -0.08 (0.86) FVC, -0.07 FEV1/FVC. Because low scatter, fifth centile corresponded -1.3 boys -1.5 girls. Malnourished had normal FEV1/FVC ratio but significant reductions ∼0.5 (∼5%) FEV1 FVC peers Survey. Children lowest, highest, zFEV1 zFVC.The results this study support use Africa. Malnutrition affects body growth, leading proportionately smaller without impairment, as shown by ratio.