Obesity and Airway Dysanapsis in Children with and without Asthma

• DOI: 10.1164/rccm.201605-1039oc
• Publication Date: 2016-08-23T20:44:03Z
• Authors: Erick Forno; Daniel J. Weiner; James Mullen; Gregory Sawicki; Geoffrey Kurland; Yueh Ying Han; Michelle M. Cloutier; Glorisa Canino; Scott T. Weiss; Augusto A. Litonjua; Juan C. Celedón
• Keywords: Vital capacity

For unclear reasons, obese children with asthma have higher morbidity and reduced response to inhaled corticosteroids.To assess whether childhood obesity is associated airway dysanapsis (an incongruence between the growth of lungs airways) morbidity.We examined relationship in six cohorts without asthma, as well clinical outcomes asthma. Adjusted odds ratios (ORs) were calculated for each cohort a combined analysis all cohorts; longitudinal analyses also performed available data. Hazard (HRs) Childhood Asthma Management Program.Being overweight or was both cross-sectional (OR, 1.95; 95% confidence interval [CI], 1.62-2.35 [for overweight/obese compared normal weight children]) 4.31; CI, 2.99-6.22 who at visits analyses. Dysanapsis greater lung volumes (FVC, vital capacity, total capacity) lesser flows (FEV1 forced expiratory flow, midexpiratory phase), indicators ventilation inhomogeneity anisotropic growth. Among severe disease exacerbations (HR, 1.38-2.75) use systemic steroids 3.22; 2.02-5.14).Obesity children. increased among may partly explain their corticosteroids.