Increased Echocardiographic Pulmonary Pressure in HIV-infected and -uninfected Individuals in the Veterans Aging Cohort Study

• DOI: 10.1164/rccm.201708-1555oc
• Publication Date: 2017-11-13T20:45:02Z
• Authors: Evan L. Brittain; Meredith S. Duncan; Joyce Chang; Olga V. Patterson; Scott L. DuVall; Cynthia A. Brandt; Kaku A. So-Armah; Matthew Goetz; Kathleen Akgun; Kristina Crothers; Courtney Zola; Joon Kim; Cynthia Gibert; Margaret Pisani; Alison Morris; Priscilla Hsue; Hilary A. Tindle; Amy Justice; Matthew Freiberg
• Keywords: Veterans Affairs

The epidemiology and prognostic impact of increased pulmonary pressure among HIV-infected individuals in the antiretroviral therapy era is not well described.To examine prevalence, clinical features, outcomes echocardiographic -uninfected individuals.This study evaluated 8,296 veterans referred for echocardiography with reported artery systolic (PASP) estimates from Veterans Aging Cohort study, an observational cohort matched by age, sex, race/ethnicity, site. primary outcome was adjusted mortality HIV status.PASP 2,831 5,465 HIV-uninfected (follow-up [mean ± SD], 3.8 2.6 yr). As compared uninfected veterans, viral load greater than 500 copies/ml (odds ratio, 1.27; 95% confidence interval [CI], 1.05-1.54) those CD4 cell count less 200 cells/μl 1.28; CI, 1.02-1.60) had a higher prevalence PASP or equal to 40 mm Hg. Hg, Hg risk death (adjusted hazard 1.78; 1.57-2.01). This persisted even participants without prevalent comorbidities 3.61; 2.17-6.01). at all values including currently considered be normal.HIV-infected people high loads low counts have people. Mortality increases lower previously recognized present comorbidities. These findings may inform decision-making regarding screening surveillance hypertension individuals.