Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer

• DOI: 10.1164/rccm.201710-2118oc
• Publication Date: 2018-06-04T21:38:01Z
• Authors: Jun-Chieh J. Tsay; Benjamin G. Wu; Michelle H. Badri; Jose C. Clemente; Nan Shen; Peter Meyn; Yonghua Li; Ting-An Yie; Tenzin Lhakhang; Evan Olsen; Vivek Murthy; Gaetane Michaud; Imran Sulaiman; Aristotelis Tsirigos; Adriana Heguy; Harvey Pass; Michael D. Weiden; William N. Rom; Daniel H. Sterman; Richard Bonneau; Martin J. Blaser; Leopoldo N. Segal
• Keywords: Prevotella

In lung cancer, upregulation of the PI3K (phosphoinositide 3-kinase) pathway is an early event that contributes to cell proliferation, survival, and tissue invasion. Upregulation this was recently described as associated with enrichment lower airways bacteria identified oral commensals.