Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

• DOI: 10.1164/rccm.201712-2410oc
• Publication Date: 2018-12-15T20:39:21Z
• Authors: Paul A. Reyfman; James M. Walter; Nikita Joshi; Kishore R. Anekalla; Alexandra C. McQu...; Stephen Chiu; Ramiro Fernandez; Mahzad Akbarpour; Ching-I Chen; Ziyou Ren; Rohan Verma; Hiam Abdala-Valencia; Kiwon Nam; Monica Chi; SeungHye Han; Francisco J. Gonz...; Saul Soberanes; Satoshi Watanabe; Kinola J. N. Will...; Annette S. Flozak; Trevor T. Nicholson; Vince K. Morgan; Deborah R. Winter; Monique Hinchcliff; Cara L. Hrusch; Robert D. Guzy; Catherine A. Bonham; Anne I. Sperling; Remzi Bag; Robert B. Hamanaka; Gökhan M. Mutlu; Anjana V. Yeldandi; Stacy A. Marshall; Ali Shilatifard; Luis A. N. Amaral; Harris Perlman; Jacob I. Sznajder; A. Christine Argento; Colin T. Gillespie; Jane Dematte; Manu Jain; Benjamin D. Singer; Karen M. Ridge; Anna P. Lam; Ankit Bharat; Sangeeta M. Bhorade; Cara J. Gottardi; G. R. Scott Budinger; Alexander V. Mish...
• Keywords: Single-Cell Analysis; Cell type

The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual during that important for disease pathogenesis.