Distinct “Immunoallertypes” of Disease and High Frequencies of Sensitization in Non–Cystic Fibrosis Bronchiectasis

Adult Aged, 80 and over Male Allergy House dust-mite Pyroglyphidae 610 Allergens Middle Aged Sensitization Asthma Bronchiectasis 3. Good health Cohort Studies 03 medical and health sciences Aspergillus 0302 clinical medicine Hypersensitivity Animals Humans :Medicine [Science] Female Immunization Aged
DOI: 10.1164/rccm.201807-1355oc Publication Date: 2018-09-28T21:17:21Z
ABSTRACT
Allergic sensitization is associated with poor clinical outcomes in asthma, chronic obstructive pulmonary disease, and cystic fibrosis; however, its presence, frequency, significance non-cystic fibrosis bronchiectasis remain unclear.To determine the frequency geographic variability that exists a pattern to common specific allergens, including house dust mite fungi, correlate such patterns airway immune-inflammatory status bronchiectasis.Patients were recruited Asia (Singapore Malaysia) United Kingdom (Scotland) (n = 238), forming Cohort of Asian Matched European Bronchiectasis, which matched patients on age, sex, severity. Specific IgE response against range allergens was determined, combined correlated outcomes. Clinically relevant patient clusters, based immune profiles ("immunoallertypes"), determined.A high multiple detected bronchiectasis, exceeding comparator cohort allergic rhinitis 149). Sensitization outcomes, decreased function more severe disease. "Sensitized bronchiectasis" classified into two immunoallertypes: one fungal driven proinflammatory, other chemokine dominant, former demonstrating poorer outcome.Allergic occurs at from different global centers. Improving endophenotyping sensitized clinically significant state, "treatable trait" permits therapeutic intervention appropriate patients, may allow improved stratification future research trials.
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