Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities

• DOI: 10.1164/rccm.202108-1967oc
• Publication Date: 2021-12-20T22:09:34Z
• Authors: John S. Kim; Gísli Thor Axelsson; Matthew Moll; Michaela R. Anderson; Elana J. Bernstein; Rachel K. Putman; Tomoyuki Hida; Hiroto Hatabu; Eric A. Hoffman; Ganesh Raghu; Steven M. Kawut; Margaret F. Doyle; Russell Tracy; Lenore J. Launer; Ani Manichaikul; Stephen S. Rich; David J. Lederer; Vilmundur Gudnason; Brian D. Hobbs; Michael H. Cho; Gary M. Hunninghake; Christine Kim Garcia; Gunnar Gudmundsson; R. Graham Barr; Anna J. Podolanczuk
• Keywords: Monocyte

Rationale: Higher blood monocyte counts are associated with worse survival in adults clinically diagnosed pulmonary fibrosis. Their association the development and progression of interstitial lung abnormalities (ILA) humans is unknown. Objectives: We evaluated associations count, other immune cell types, ILA, high-attenuation areas, FVC four independent cohorts. Methods: included participants measured computed tomographic (CT) imaging enrolled MESA (Multi-Ethnic Study Atherosclerosis, n = 484), AGES-Reykjavik (Age/Gene Environment Susceptibility Study, 3,547), COPDGene (Genetic Epidemiology COPD, 2,719), ECLIPSE (Evaluation COPD Longitudinally to Identify Predictive Surrogate End-points, 646). Measurements Main Results: After adjustment for covariates, a 1-SD increment count was ILA (odds ratio [OR], 1.3; 95% confidence interval [CI], 1.0–1.8), (OR, 1.2; CI, 1.1–1.3), 1.2–1.4), 1.0–1.4). A higher over 5 years 1.0–1.3). Compared without there percentage activated monocytes among those MESA. greater areas lower COPDGene. Associations types were less consistent. Conclusions: presence FVC.