Plasticity of Individual Lung Function States from Childhood to Adulthood

• DOI: 10.1164/rccm.202203-0444oc
• Publication Date: 2022-11-21T21:06:32Z
• Authors: Gang Wang; Jenny Hallberg; Rosa Faner; Hans-Jacob Koefoed; Simon Kebede Merid; Susanna Klevebro; Sophia Björkander; Olena Gruzieva; Göran Pershagen; Marianne van Hage; Stefano Guerra; Matteo Bottai; Antonios Georgelis; Ulrike Gehring; Anna Bergström; Judith M. Vonk; Inger Kull; Gerard H. Koppelman; Alvar Agusti; Erik Melén
• Keywords: respiratory health; Adolescent; multiple-breath washout; Original Articles; asthma; Asthma; Respiratory Function Tests; Young Adult; 03 medical and health sciences; 0302 clinical medicine; inflammation; Hypersensitivity; Humans; early life risk factors; Child; Lung; Respiratory Sounds

Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. Objectives: To explore plasticity individual function states childhood. Methods: Prebronchodilator FEV1 z-scores determined at age 8, 16, and 24 years in Swedish population-based birth cohort BAMSE (Swedish abbreviation Child [Barn], Allergy, Milieu, Stockholm, Epidemiological study) (N = 3,069) were used. An unbiased, data-driven dependent mixture model was applied to state chains. Lung catch-up defined as participants moving from low or very normal high states, growth failure states. At years, we compared respiratory symptoms, small airway (multiple-breath washout), circulating inflammatory protein levels, by using proteomics, across Models replicated independent Dutch PIAMA (Prevention Incidence Asthma Mite Allergy) cohort. Measurements Main Results: Five identified BAMSE. observed 74 (14.5%) with 36 (2.4%) respectively. The occurrence PIAMA. Early-life risk factors cumulatively associated state, well (inverse association) failure. airflow limitation, dysfunction adulthood. Proteomics IL-6 CXCL10 (C-X-C motif chemokine 10) potential biomarkers impaired development. Conclusions: Individual are plastic, including