Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia–associated Pulmonary Hypertension

• DOI: 10.1164/rccm.202203-0570oc
• Publication Date: 2022-11-15T20:30:28Z
• Authors: Samuel J. Gentle; Colm P. Travers; Matthew Clark; Waldemar A. Carlo; Namasivayam Ambal...
• Keywords: Bronchopulmonary Dysplasia; Ductus arteriosus

Background: Extremely preterm infants with evolving bronchopulmonary dysplasia (BPD) are at risk for development of BPD-associated pulmonary hypertension (BPD-PH). The presence and duration a patent ductus arteriosus (PDA) shunt may be modifiable factor BPD-PH development. Methods: Retrospective case-control study among 22w 0d to 28w 6d who remained on respiratory support postnatal day 28 the University Alabama Birmingham from 2017-2020. Infants were diagnosed (cases) by echocardiography compared without (controls). Data echocardiograms performed during hospitalization after included. Generalized linear models adjusted covariates that differed significantly between groups. A probit analysis related ductal patency BPD-PH. Results: 138 developed BPD alone 82 Following adjustment differing groups, both PDA (aOR 4.29; 95% CI 1.89 – 9.77) moderate large 4.15; 1.78 9.64) discharge. By each additional month hemodynamically significant exposure was associated an increased probability composite outcome discharge or death coefficients 0.40 (p<0.001) 0.45 respectively. Conclusions: In extremely 28, longer