Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia

• DOI: 10.1164/rccm.202210-2015oc
• Publication Date: 2023-07-18T21:12:36Z
• Authors: Minzhe Guo; Kathryn A. Wikenh...; Joseph A. Kitzmiller; Cheng Jiang; Guolun Wang; Allen Wang; Sebastian Preissl; Xiaomeng Hou; Justin Buchanan; Justyna A. Karolak; Yifei Miao; David B. Frank; William J. Zacharias; Xin Sun; Yan Xu; Mingxia Gu; Pawel Stankiewicz; Vladimir V. Kalin...; Jennifer A. Wambach; Jeffrey A. Whitsett
• Keywords: Cell type

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal developmental disorder lung morphogenesis caused by insufficiency FOXF1 (forkhead box F1) transcription factor function. The cellular and transcriptional mechanisms which deficiency disrupts human formation are unknown.