Endotypes of Exacerbation in Bronchiectasis: An Observational Cohort Study

• DOI: 10.1164/rccm.202310-1729oc
• Publication Date: 2024-05-08T14:16:13Z
• Authors: Yonghua Gao; Hollian Richardson; Alison J. Dicker; Alun Barton; Elena Kuzmanova; Michal Shteinberg; Lidia Perea; Pieter C. Goeminne; Erin Cant; Chandani Hennayake; Jennifer Pollock; Hani Abo Leyah; Hayoung Choi; Eva Polverino; Francesco Blasi; Tobias Welte; Stefano Aliberti; Merete Long; Amelia Shoemark; Oriol Sibila; Jeffrey T. J. Huang; James D. Chalmers
• Keywords: Male; bronchiectasis; Microbiota; Sputum; microbiome; 610; /dk/atira/pure/subjectarea/asjc/2700/2706; bronchiectasis; exacerbations; microbiome; proteomics; viruses;; Middle Aged; Bronchiectasis; /dk/atira/pure/subjectarea/asjc/2700/2740; Cohort Studies; proteomics; name=Critical Care and Intensive Care Medicine; exacerbations; Disease Progression; Humans; viruses; Female; Leukocyte Elastase; name=Pulmonary and Respiratory Medicine; Aged

Bronchiectasis is characterized by acute exacerbations, but the biological mechanisms underlying these events are poorly characterized.