A case of Cronkhite-Canada syndrome treated by steroid pulse therapy

• DOI: 10.11641/pde.84.1_168
• Publication Date: 2014-06-20T23:05:51Z
• Authors: Yosuke Yamamoto; Toshiyuki Tahara
• Keywords: Prednisolone; Topical steroid

A 47-year-old man visited our hospital with the chief complaints of diarrhea, dysgeusia, alopecia and onychodystrophy. Endoscopic examinations revealed an edematous reddish mucosa many polypoid lesions in stomach colon. Cronkhite-Canada syndrome was diagnosed patient treated intravenous prednisolone. The symptoms improved gradually, however, remission not achieved. At one month after treatment, serum albumin level still persisted. We then decided to administer steroid pulse therapy. With this therapy, dramatically, maintenance therapy initiated betamethasone, which has a longer half-life than patient’s condition improved, repeat endoscopy improvement mucosal inflammation. This case indicates that may be useful for at least proportion patients Cronkhite Canada syndrome, also helping deciding treatment policy.