Study of Prognostic Factors of Death in Children with Sickle Cell Diseases Followed at the Albert Royer National Children's Hospital Center, Dakar, Senegal

• DOI: 10.11648/j.ajp.20200601.11
• Publication Date: 2020-07-13T08:19:26Z
• Authors: Boubacar Gueye; Cheikh Tacko Diop; Ndéye Marième Diagne; Aminata Paye; Ibrahima Diagne
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Objectives. The objectives of our study are: i) estimate the survival time cases sickle cell diseases monitored at Albert Royer National Children's Hospital Center, Dakar, Senegal from 1990 to 2010, ii) identify prognostic factors related deaths. Methods. Comprehensive and retrospective analysis death 1650 patients with disease followed in management unit Center January 1^st, 1991 December 31, 2010 (20 years). 17 variables were studied: gender, ethnicity, geographical origin, age patient onset disease, follow-up, number vaso-occlusive crisis last year follow-up duration which is ≥72h, type hemoglobinopathy, baseline hemoglobin level, fetal level diagnosis, vaccination least one antigen, regular folic acid intake, penicillin hydroxyurea therapy, acute complications (severe infections, severe anemia serious accidents) chronic complications. Cox model was used. Results. We conducted observations 44 deaths, a lethality 2.6%. incidence rate 3.51 deaths per 100 person-years. highlighted significantly explain (p < 0.05). Vaccination antigen existence improved survival. However, (duration ≥72h), accidents very low (≤5mg/100 mn), early late (≥15 months) reduced Conclusions. prognosis (ARNCHC) difficult establish. In fact, addition genetic, clinical evolutionary factors, there are poorly understood environmental socio-economic that affect A prospective would shed more light on children disease.