MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling

• DOI: 10.1165/rcmb.2007-0336rc
• Publication Date: 2007-12-14T02:17:13Z
• Authors: Keiko Ueno; Takeshi Koga; Kosuke Kato; Douglas T. Golenbock; Sandra J. Gendler; Hirofumi Kai; K. Chul Kim
• Keywords: MUC1; Flagellin

MUC1 (MUC1 in humans and Muc1 nonhuman species) is a transmembrane mucin-like glycoprotein expressed epithelial cells lining various mucosal surfaces as well hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, our studies cultured revealed MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting anti-inflammatory role. Here demonstrate other TLR (TLR2, 3, 4, 7, 9) also by MUC1/Muc1. The results from this study suggest may play crucial role during airway infection inflammation pathogenic bacteria viruses.