pH Sensitive Triptolide-Loaded Liposome Calcium Phosphate Nanoparticles Exhibit Enhanced Anti-Tumor Activities Against Ovarian Cancer Without Damaging the Reproductive System

• DOI: 10.1166/jbn.2017.2429
• Publication Date: 2018-09-28T03:23:52Z
• Authors: Dan Ru; Chenhuan Ding; Lei Liu; Huan Liu; Ming Shen; Yourong Duan; He Li
• Keywords: Triptolide; Tripterygium wilfordii; Biodistribution; Ovarian tumor

Triptolide (TP), a diterpenoid triepoxide purified from the Chinese traditional medicine Tripterygium wilfordii Hook F (TWHF), possesses potent anti-tumor activities against several malignancies, including ovarian cancer. However, its short half-life in circulation and severe reproductive toxicity prohibit clinical use of TP. In this study, we engineered novel nanoparticles consisting calcium phosphate conjugated TP-loaded liposomes (TP@Lips-Ca/P), constituted mPEGDPPE2000, to improve time, stability biodistribution The average particles size was 134.1 nm, drug loading efficiency encapsulation were 1.31 ± 0.13% 72.31 3.11% respectively. TP@Lips-Ca/P exhibits greatly enhanced effects on SKOV-3 cancer cells compared TP alone. We further demonstrated that apoptosis induced by resulted excessive accumulation reactive oxygen species (ROS). ROS activates MAPK signal pathway, leading induction inhibition tumor growth. addition, found displays significantly reduced toward female system free conclusion, are promising chemotherapy approach for