Gelatin-Encapsulated Magnetic Nanoparticles for pH, Redox, and Enzyme Multiple Stimuli-Responsive Drug Delivery and Magnetic Resonance Imaging

• DOI: 10.1166/jbn.2017.2433
• Publication Date: 2018-09-28T07:23:52Z
• Authors: Anhui Qi; Lin Deng; Xi Liu; Shu Wang; Xiaodi Zhang; Binbin Wang; Linlin Li
• Keywords: Gelatin; Cystamine

A new kind of magnetic gelatin-encapsulated nanoassembly was fabricated as a multifunctional drug delivery system (DDS) with pH, redox, and enzyme stimuli-responsive release for cancer theranostics. Cystamine-modified gelatin used to encapsulate doxorubicin (Dox) an anticancer Fe₃O₄ the resonance imaging (MRI) contrast agent assembly into via formation oil-in-water microemulsion. Such DDS can provide long-term Dox more effective availability, since acidic environment, high glutathione (GSH) matrix metalloproteinase (MMP) level tissues. And it would beneficial accumulation around tumor through enhanced penetration retention (EPR) effect, deeper because its enzyme-degradable size-changeable ability. This vehicle had good biocompatibility. It effectively reduce efflux drugs when these nanoparticles were uptaken by cells. Besides, Dox-Fe₃O₄@gelatin be T₂-weighted MRI.