FTO-Mediated lncRNA-FNDRR Axis Demethylation Promotes Cell Proliferation, Invasion, and Migration in Esophageal Squamous Cell Carcinoma

• DOI: 10.1166/jbn.2023.3623
• Publication Date: 2023-08-23T04:40:59Z
• Authors: Xuyang Liang; Libo Wang; Lu Wang; Shuxian Zhang; Ling Ren; Shouying Li; Jing Xu; Ping Xu
• Keywords: Demethylase

Esophageal squamous cell carcinoma (ESCC) is characterized by a poor prognosis and has significant impact on patient survival quality of life. The role N6-methyladenosine (m6A) modification in the regulation long non-coding RNAs (lncRNAs) messenger (mRNAs) been reported various diseases, including cancer. Although clinical value lncRNA-FNDRR predicting ESCC well-established, its molecular mechanism remains incompletely understood. Therefore, this study, we aimed to investigate involvement m6A-lncRNA-FNDRR axis progression. Results revealed that overexpression exerted inhibitory effects proliferation, migration, invasion. Interestingly, knockdown demethylase enzyme fat mass obesity-associated protein (FTO) resulted similar those achieved overexpressing cells. Moreover, found FTO had ability reverse m6A lncRNA-FNDRR. Importantly, simultaneous promoted proliferation metastasis, suggesting synergistic effect between these two factors. These results provide valuable insights into mechanisms underlying highlight significance modifications context. Further investigations are warranted deepen our understanding disease explore potential therapeutic strategies.