Chitosan/Polyurethane Blended Fiber Sheets Containing Silver Sulfadiazine for Use as an Antimicrobial Wound Dressing

• DOI: 10.1166/jnn.2014.9581
• Publication Date: 2014-04-27T19:54:28Z
• Authors: Sang Jin Lee; Dong Nyoung Heo; Ji-Hoi Moon; Ha Na Park; Wan-Kyu Ko; Min Soo Bae; Jung Bok Lee; Se Woong Park; Eun-Cheol Kim; Chang Hoon Lee; Bock-Young Jung; Il Keun Kwon
• Keywords: Silver sulfadiazine; Electrospinning

Electrospun chitosan (CTS) nanofibers have been well known for use as a wound dressing in the biomedical field. Nevertheless, fatal bacterial infections are still serious problem when CTS used treatment. In this study, we designed novel based on blending with polyurethane (CTS/PU) containing silver sulfadiazine (AgSD) order to enhance both antibacterial activity and mechanical strength. This fiber sheet was produced using electrospinning (ELSP) technique. The CTS/PU AgSD characterized by energy-dispersive X-ray spectroscopy (EDX). physicochemical properties of CTS/PU/AgSD sheets were also thermogravimetric analysis (TGA) Fourier transform infrared (FT-IR). electrospun fibers morphologically scanning electron microscopy (SEM) transmission (TEM). For an vitro evaluation, tested their against gram-negative Pseudomonas aeruginosa (P. aeruginosa), gram-positive Staphylococcus aureus (S. aureus) Methicillin-resistant (MRSA). results indicate that strong antimicrobial displayed inhibition growth prevention infection during healing process. These material would be good material.