Versatile Mesoporous Nanoparticles for Cell Applications

• DOI: 10.1166/jnn.2021.19054
• Publication Date: 2021-03-03T12:11:12Z
• Authors: Román Seco Gudiña; Susana Yáñez Vilar; Manuel González G...; Zulema Vargas Osorio; María de la Fuente; Yolanda Piñeiro R...; Rafael López; José Rivas
• Keywords: Surface Modification; Rhodamine B

Mesoporous silica nanostructures are emerging as a promising platform able to deal with challenges of many different applications in fields such biomedicine and nanotechnology. The versatile physical functional properties these materials like high specific surface area, ordered porosity, chemical stability under temperature pH variations, biocompatible performance, offers new approaches biomedical ranging from drug delivery systems biosensing, cell tissue engineering. Their morphology, size textural can be easily tailored by means control, giving rise variety hexagonal (SBA15, MCM41) or cubic (SBA16) arrangement channels pore 1.3 10 nm. Based on the versatility their silane surface, plethora hybrid mesoporous matrices prepared incorporating functionalities contrast enhancement for magnetic resonance imaging, magnetic/plasmonic hyperthermia, simple grafting superparamagnetic metal oxides (Fe 3 O 4 , transition ferrites) nanoparticles, noble (Au, Ag) fluorescent moieties (fluorescein, rhodamine) biological agents (mAb, mRNA, etc). goal this work is present development, facile soft template method, nanospheres 20 350 nm (by control), highlight its (with rhodamine polydopamine) compatibility efficient uptake cultured HeLa cells. combined, physicochemical biological, indicate that MSNs good candidates tagging, gene transfer targeted therapies.