Body Mass Index Has a Linear Relationship with Cerebrospinal Fluid Pressure

• DOI: 10.1167/iovs.11-8220
• Publication Date: 2012-02-09T12:13:49Z
• Authors: John P. Berdahl; David Fleischman; Jana Zaydlarova; Sandra Stinnett; R. Rand Allingham; Michael P. Fautsch
• Keywords: Cerebrospinal fluid pressure

To examine the relationship between body mass index (BMI) and cerebrospinal fluid pressure (CSFP), as low BMI CSFP have recently been described risk factors for primary open-angle glaucoma (POAG).This was a retrospective review of electronic medical records patients who had measured by lumbar puncture data to calculate at Mayo Clinic (Rochester, MN). Exclusion criteria included diagnoses, surgical procedures medications known affect CSFP. Mean each unit calculated. The probabilities were two-tailed, α level set P < 0.05. Patients with documented BMI, CSFP, intraocular (IOP) analyzed IOP BMI.A total 4235 patients, primarily Caucasian descent, met entry criteria. Median 26 mean 10.9 ± 2.6 mm Hg. increase in increasing linear an r(2) = 0.20 (P 0.001). increased 37.7% from 18 (8.6 2.1 Hg) 39 (14.1 2.5 Hg). (0.21) model sex similar BMI-only (0.20). There no relation within subgroup study population (r (2) 0.005; 0.14).CSFP has positive, BMI. is not influenced If influences POAG, then individuals lower may developing POAG. Similarly, higher be protective.