Photopic Negative Response versus Pattern Electroretinogram in Early Glaucoma

• DOI: 10.1167/iovs.12-11201
• Publication Date: 2013-01-10T23:51:36Z
• Authors: Dunja Preiser; Wolf A. Lagrèze; Michael Bach; Charlotte M. Polo...
• Keywords: Electroretinography

Photopic negative response (PhNR) and pattern electroretinogram (PERG) are electrophysiological markers of retinal ganglion cell function; both reduced in glaucoma. We compared PhNR PERG different stages the disease.Eleven eyes with preperimetric glaucoma (glaucomatous optic disc normal field); 18 manifest glaucoma; 26 normals were included. obtained (flash strength from 0.1-4 cd·s/m(2)) steady-state analyzed amplitude (baseline to 72 ms trough); PhNR/b-wave ratio; amplitude; ratio (0.8°/16°).Identification structure was only reliable ≥1 cd·s/m(2) flash strength; receiver operating characteristics (ROC) area under curve (AUC) changed little 1 4 cd·s/m(2). Both (amplitude ratio) more so AUCs based on PhNR/PERG amplitudes not significantly chance (AUCs 0.61/0.59), but significant (0.78/0.76); ratios groups (0.80/0.73 0.80/0.79). In spite that, correlated (r = 0.22 across all groups); an ROC a combination reached 0.85/0.90 for preperimetric/manifest glaucoma.Both performed similarly detect both, better than amplitudes. The has advantage requiring clear optics refractive correction; being recorded natural pupils.