Determinants of Macular Thickness Using Spectral Domain Optical Coherence Tomography in Healthy Eyes: The Singapore Chinese Eye Study

• DOI: 10.1167/iovs.13-12436
• Publication Date: 2013-11-13T03:27:00Z
• Authors: Preeti Gupta; Elizabeth Sidhartha; Yih Chung Tham; Daniel Kai Peng Chua; Jiemin Liao; Ching-Yu Cheng; Tin Aung; Tien Yin Wong; Carol Y. Cheung
• Keywords: Adult; Aged, 80 and over; Male; Aging; Singapore; 610; 500; Reproducibility of Results; Middle Aged; 03 medical and health sciences; 0302 clinical medicine; Macular thickness; Reference Values; Population Surveillance; Spectral-domain OCT; Humans; Female; Macula Lutea; Tomography, Optical Coherence; Population-based study; Aged; Retrospective Studies

Purpose.: We determined ocular and systemic factors influencing macular thickness measured by spectral-domain optical coherence tomography (SD-OCT) in a population-based sample of healthy eyes. Methods.: recruited 490 Chinese adults, aged 40 to 80 years, from the Singapore Eye Study, survey. All participants underwent comprehensive eye examination standardized interview. The SD-OCT (Cirrus HD-OCT, software version 6.0) was used measure range parameters (central foveal subfield thickness, average inner outer overall cube volume). Linear regression analyses were performed examine effects various on thickness. Results.: mean (standard deviation) age subjects 53.17 (6.14) years 50.0% them male. central subfield, inner, thicknesses 250.38 (20.58), 319.33 (14.40), 276.67 (11.94) μm, respectively. 280.25 (11.42) μm volume 10.09 (0.41) mm3. Sex, age, axial length (AL) are that influenced thicknesses. Thinner associated with female sex (4.46 thinner compared males, P < 0.001), older (0.38 decrease per each year increase longer AL (2.34-μm mm AL, whereas (13.5 0.001) shorter (3.33-μm 0.001). Conclusions.: Female sex, independently ethnic Chinese. These should be taken into consideration when interpreting measurements SD-OCT.