Distinct Pathways of Macular Atrophy in Type 3 Macular Neovascularization Associated With AMD

• DOI: 10.1167/iovs.65.3.18
• Publication Date: 2024-03-12T10:55:31Z
• Authors: Enrico Borrelli; Costanza Barresi; Federico Ricardi; Alessandro Berni; Domenico Grosso; Pasquale Viggiano; Paola Marolo; Ugo Introini; Michele Reibaldi; Francesco Bandello
• Keywords: Drusen

Purpose: To explore the occurrence of macular atrophy (MA) in eyes with age-related degeneration (AMD)-associated Type 3 neovascularization (MNV) treated anti-vascular endothelial growth factor (anti-VEGF) therapy. Importantly, we aimed at describing existence separate pathways leading to MA. Methods: We analyzed 41 participants (41 eyes) treatment-naïve MNV who were followed up for a duration 12 months after beginning anti-VEGF At one-year follow-up visit, optical coherence tomography (OCT) scans reviewed presence MA regions interest (ROIs) selected and traced back their original dominant baseline lesion (i.e., precursor) through previous serially captured OCT scans. Baseline lesions included precursors associated development exudation causes external itself. Results: was graded be present 38 (92.7%) out eyes. These 78 ROIs divided into two subgroups according precursor lesion, yielding group 53 caused by physical harm from neovessels, collapse serous pigment epithelium detachment, fibrosis) 25 itself drusen or subretinal drusenoid deposits). Conclusions: Eyes are commonly complicated include MNV, as well unrelated process