First Human Results With the 256 Channel Intelligent Micro Implant Eye (IMIE 256)

• DOI: 10.1167/tvst.10.10.14
• Publication Date: 2021-10-27T15:32:22Z
• Authors: Huizhuo Xu; Xingwu Zhong; Changlin Pang; Jing Zou; Wangling Chen; Xianggui Wang; Shanxiang Li; Yuntao Hu; Didier S. Sagan; Philip T. Weiss; Yangyi Yao; Jiayi Xiang; Margot S. Dayan; Mark S. Humayun; Yu-Chong Tai
• Keywords: Visual prosthesis; Retinal implant

Purpose: To report on the safety and efficacy of 256-channel Intelligent Micro Implant Eye epiretinal prosthesis system (IMIE 256). Methods: The IMIE 256 implants were implanted in right eyes five subjects with end-stage retinitis pigmentosa. Following implantation, underwent visual rehabilitation training for 90 days, their performance was evaluated using grating acuity test, Tumbling E direction motion, square localization, orientation mobility test. evaluate 256, all adverse events recorded. Results: Subjects performed significantly better evaluations as compared at baseline or off. There a steady improvement each observation interval, indicating that and/or practice helped use 256. two serious events—electrode array movement low intraocular pressure one subject, which resolved surgery. no other observed except those expected course postoperative healing. Conclusions: These results show an improved profile Argus II implant. Further clinical trials are needed to confirm these larger number over longer durations. Translational Relevance: our knowledge, this study reports first in-human data from high-density (256 electrodes) implant restore sight subset blind patients.