ZEISS PLEX Elite 9000 Widefield Optical Coherence Tomography Angiography as Screening Method for Early Detection of Retinal Hemangioblastomas in von Hippel–Lindau Disease

• DOI: 10.1167/tvst.13.2.8
• Publication Date: 2024-02-12T15:31:03Z
• Authors: Stefan J. Lang; Michelle Dreesbach; Yannik Laich; Andreas Glatz; Daniel Boehringer; Viviane Grewing; Marianne Fritz; Felicitas Bucher; Wolf A. Lagrèze; Peter M. Maloca; Thomas Reinhard; Clemens Lange; Hansjuergen Agostini; Michael Reich
• Keywords: Fundus (uterus); Fundus fluorescein angiography

Purpose: To evaluate early detection of retinal hemangioblastomas (RHs) in von Hippel–Lindau disease (VHLD) with widefield optical coherence tomography angiography (wOCTA) compared to the standard care ophthalmologic VHLD screening a routine clinical setting. Methods: We conducted prospective comparisons three methods: wOCTA, ophthalmoscopy, and fluorescein (FA), which was performed only uncertain cases. The numbers detected RHs were among methods. underlying causes for lack investigated. Results: In 91 eyes (48 patients), 67 observed (mean, 0.74 ± 1.59 RH per eye). FA eight eyes. Ophthalmoscopy overlooked 25 35 by wOCTA (71.4%) due background color choroid (n = 5), small tumor size 13), masking bright fundus reflex 2), surrounding scars 5). However, missed 29 peripheral location (43.3%). overall rates up 37% on basis ophthalmoscopy alone, 52% 89% FA. Within area covered 46.7% 92.1% 73.3% Conclusions: low rate using is almost exclusively caused its inability visualize entire retina. Therefore, unclear cases, necessary after ophthalmoscopy. Translational Relevance: imageable area, shows high therefore may be suitable improve VHLD.