Reduced Retinal Vascular Density and Skeleton Length in Amblyopia

• DOI: 10.1167/tvst.13.5.21
• Publication Date: 2024-05-23T15:31:10Z
• Authors: Wenxin Su; Li Ma; Kexin Li; Yiqun Hu; Yanqing Mao; Wenbin Xie; Xinya Hu; Tao Huang; Junfeng Lv; Mingxuan Wang; Biao Yan; Xue Yao; Xiaohe Yan; Jiayi Zhang
• Keywords: Fundus (uterus)

Purpose: This study aimed to investigate the possible relationship between retinal vascular abnormalities and amblyopia by analyzing structures of fundus images. Methods: In this observational study, images were collected from 36 patients with unilateral amblyopia, 33 bilateral healthy control volunteers. We developed a customized training algorithm based on U-Net digitalize vasculature in quantify density (area fractal dimension), skeleton length, number bifurcation points. For statistical comparisons, divided participants into two groups. The amblyopic eyes fellow formed paired group, while controls independent group. Results: area (P = 0.007), dimension length 0.002) significantly smaller than those eyes. significant decreases 0.006) 0.048) observed compared control. was also correlated best-corrected visual acuity Conclusions: demonstrated that control, indicating an association changes features state amblyopia. Translational Relevance: Our presents are more biologically interpretable for both clinicians researchers.