Different Effect of Media Opacity on Vessel Density Measured by Different Optical Coherence Tomography Angiography Algorithms

• DOI: 10.1167/tvst.9.8.19
• Publication Date: 2020-07-13T16:34:09Z
• Authors: Jinyu Zhang; Fang Yao Tang; Carol Y. Cheung; Haoyu Chen
• Keywords: Opacity

Several studies show that media opacity reduces vessel density (VD) measured by image processing algorithms of optical coherence tomography angiography (OCTA). However, different models OCTA designed their own and computational methods, which may have effects on VD. This study is aimed to investigate the impact a simulated model quantitative measurement two devices.A spectral-domain based (Cirrus 5000; Carl Zeiss Meditec) swept-source (Triton DRI-OCT, Topcon Inc.) were used retinal microvasculature at macula using 3 × mm scanning protocol from 22 eyes healthy subjects. Media was with neutral-density filters (optical (OD)λ=840nm ranges 0.10-0.48 in Cirrus; ODλ=1050nm 0.15-0.51 Triton). The placed front each eye, signal strength (SS) or intensity (SSI) recorded during imaging. parafoveal VD superficial capillary plexus then built-in software devices. correlations among OD, SS/SSI, analyzed.Increased OD significantly correlated decreased SS SSI (rs = -0.576 -0.922, respectively, both P < 0.001) Cirrus Triton, respectively. Although increased -0.539, 0.001), there no significant correlation between Triton -0.143, 0.137).The effect devices.This demonstrates devices, suggesting caution must be taken when interpreting OCTA, particularly individuals opacity.