A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans

• DOI: 10.1172/jci.insight.124819
• Publication Date: 2019-05-30T16:01:31Z
• Authors: Evelina Charidemou; Tom Ashmore; Xuefei Li; Ben D. McNally; James A. West; Sonia Liggi; Matthew Harvey; Elise Orford; Julian L. Griffin
• Keywords: Lipogenesis; De novo synthesis

BACKGROUND. Dietary changes have led to the growing prevalence of type 2 diabetes and nonalcoholic fatty liver disease. A hallmark both disorders is hepatic lipid accumulation, derived in part from increased de novo lipogenesis. Despite popularity high-protein diets for weight loss, effect dietary protein on lipogenesis poorly studied. We aimed characterize synthesis.