Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats

• DOI: 10.1172/jci.insight.139789
• Publication Date: 2020-10-01T15:01:40Z
• Authors: Feng Gu; E. Benjamin Randall; Steven Whitesall; Kimber Converso-B...; Brian E. Carlson; Gregory D. Fink; Daniel E. Michele; Daniel A. Beard
• Keywords: Etiology; Disengagement theory; Pathophysiology

The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying pathophysiology this model, we analyzed dynamic baroreflex response to spontaneous fluctuations in arterial pressure conscious SHRs, as well Wistar-Kyoto (WKY), Dahl salt-sensitive, salt-resistant, and Sprague-Dawley rat. Observations revealed existence long intermittent periods (lasting up several minutes) engagement disengagement control heart rate. Analysis these predictive relationship between increased mean progressive was present SHR WKY strains but absent others. This yielded hypothesis lower proportion versus compared contributes (or blood pressure) WKY. Results experiments using sinoaortic baroreceptor denervation were consistent dysfunction SHR. Thus, study provides experimental evidence for roles long-term regulation animal model.