A system-view of Bordetella pertussis booster vaccine responses in adults primed with whole-cell versus acellular vaccine in infancy

• DOI: 10.1172/jci.insight.141023
• Publication Date: 2021-03-09T17:01:18Z
• Authors: Ricardo da Silva ...; Ferran Soldevila; Mikhail Pomaznoy; Mariana Babor; Jason Bennett; Yuan Tian; Natalie Khalil; Yu Qian; Aishwarya Mandava; Richard H. Scheue...; Mario Cortese; Bali Pulendran; Christopher D. Petro; Adrienne P. Gilkes; Lisa A. Purcell; Alessandro Sette; Bjoern Peters
• Keywords: Priming (agriculture); Vaccine efficacy

The increased incidence of whooping cough worldwide suggests that current vaccination against Bordetella pertussis infection has limitations in quality and duration protection. resurgence been linked to the introduction acellular vaccines (aP), which have an improved safety profile compared with previously used whole-cell (wP) vaccines. To determine immunological differences between aP wP priming infancy, we performed a systems approach immune response booster vaccination. Transcriptomic, proteomic, cytometric, serologic profiling revealed multiple shared responses different kinetics across cohorts, including increase blood monocyte frequencies strong antigen-specific IgG responses. Additionally, found prominent subset aP-primed individuals (30%) differential signature, higher levels expression for CCL3, NFKBIA, ICAM1. Contrary individuals, this displayed PT-specific IgE after boost IgG4 IgG3 antibodies FHA FIM2/3 at baseline boost. Overall, results show that, while broad patterns Tdap overlap aP- wP-primed present divergent response. These findings provide candidate targets study causes correlates waning immunity