Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis

• DOI: 10.1172/jci.insight.141420
• Publication Date: 2021-05-04T16:00:44Z
• Authors: Kyle L. Poulsen; Xiude D. Fan; Christopher D. Ki...; Emily Huang; Xiaoqin Wu; Megan R. McMullen; Lin Leng; Richard Bucala; Meritxell Ventura...; Josepmaria Argemi; Ramon Bataller; Laura E. Nagy
• Keywords: CCL20; CCL4

The chemokine system of ligands and receptors is implicated in the progression alcohol-associated hepatitis (AH). Finding upstream regulators could lead to novel therapies. This study involved coordinated expression chemokines livers healthy controls (HC) patients with AH 2 distinct cohorts various chronic liver diseases. Studies cultured hepatocytes tissue-specific KO were used for mechanistic insight into a potential regulator AH. Selected C-X-C members IL-8 family C-C CCL20 highly associated compared HC but not diseases other etiologies (nonalcoholic fatty disease [NAFLD] C virus [HCV]). Our previous studies implicate macrophage migration inhibitory factor (MIF) as pleiotropic cytokine/chemokine coordinately regulate LPS-stimulated multiple was dependent on MIF. Gao-binge ethanol feeding mice induced similar WT mice; this prevented hepatocyte-specific Mif-KO (MifΔHep) mice. demonstrates that exhibit specific, expressed signature hepatocyte-derived MIF might drive inflammatory response.