CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking

• DOI: 10.1172/jci.insight.148652
• Publication Date: 2021-07-13T16:01:46Z
• Authors: Tábata Takahashi ...; Ashraf Al-Sbiei; Ghada Bashir; Yassir Awad Mohamed; Ranieri Coelho Sa...; Lucila Akune Barr...; Sarah Maria da Si...; Cristina Worm Weber; Janaíra Fernandes...; Carolina Sanchez ...; Carolina Prando; Mayra B. de Barro...; Igor Jurisica; Maria J. Fernande...; Hans D. Ochs; Antonio Condino-Neto; Basel K. Al-Ramadi; Otavio Cabral-Mar...
• Keywords: Granulopoiesis

Neutrophils are produced in the BM a process called granulopoiesis, which progenitor cells sequentially develop into mature neutrophils. During developmental process, is finely regulated by distinct transcription factors, neutrophils acquire ability to exit BM, properly distribute throughout body, and migrate infection sites. Previous studies have demonstrated that CD40 ligand (CD40L) influences hematopoiesis granulopoiesis. Here, we investigate effect of CD40L on neutrophil development trafficking performing functional transcriptome analyses. We found signaling plays an essential role early stages generation BM. Moreover, modulates transcriptional signatures, indicating this molecule enables traffic body response inflammatory signals. Thus, our study provides insights complex relationships between it suggests potentially novel nonredundant function.